Urbanization and industrialization in many parts of world contaminate ground and surface water resources. Present study is design to investigate the hydrochemical characteristics, spatial distribution of major cations/anions, heavy metal pollution and associated health risk assessment of ground water. In total 30 ground water samples were taken from different urban localities of Multan suggesting elevating level of EC and TDS. Major cations and anions except SO42- and HCO3- in one area were below World Health Organization (WHO) guidelines for drinking purpose. Hydrochemical results also indicates ground water pollution is attributed to rock-water interaction. Medium to low microbial concentration was also noted in ground water by seepage of sewage water. Elevated heavy metal concentration (As, Cd, Cr & Fe) was recorded in most of the sampled ground water. Piper plot indicates mixed water type with Na+/K+ and Na+/HCO3- type. Water Quality Index (WQI) and Heavy metal Pollution Index (HPI) ranked ground water of Multan from very poor to hazardous posing health hazards. Total hazard quotient value by ingesting ground water exceeds non-carcinogenic threshold HQ = 1.0 in half of ground water samples. Potential cancer risk was obtained for children in selected areas. Therefore, an effective management and monitoring system is applied in study area to safeguard the local community from potential illness. Major response action require to restore ground water quality is to cut off contamination sources such as industrial effluents, fertilizers and pesticides application. Installing water treatment plants in study area to reduce cancer risk for local community is an effective and tangible solution.