The purpose of this research was to comprehensively evaluate the performance and emission characteristics of a diesel engine using a novel fuel blend comprising a hybrid nano-emulsified JME-Diesel blend (B20). The fuel blend consisted of a mixture of 50 ppm of ferric oxide (Fe2O3) and Silicon Dioxide (SiO2) nanoparticles. The engine's performance and emissions were investigated under different load conditions ranging from 0 to 100%. This study involved conducting a series of experiments on an engine to evaluate the engine's efficiency (BTE) and fuel consumption (BSFC). Additionally, emissions in exhaust including NOx, CO, HC, and excess O2 were measured to assess the environmental impact of the hybrid nano-emulsified JME-Diesel blend (B20). The results obtained from the experimental investigations revealed that the adding of nano Fe2O3 and SiO2 to the JME-Diesel blend improved the engine's performance and reduced emissions. An increase in the proportion of nanoparticles 50 ppm led to a significant improvement in BTE, while simultaneously reducing BSFC. Regarding emissions, the hybrid nano-emulsified JME-Diesel blend (B20) demonstrated a considerable reduction in CO2, CO, and HC emissions than neat diesel . Notably, the emission reductions were more pronounced as the nanoparticle proportion increased. This indicates the potential of the hybrid nano-emulsified fuel blend to contribute towards environmental sustainability and mitigate the adverse effects of diesel engine emissions. In insinuation, the results demonstrate the promising characteristics of an engine fueled with a hybrid nano-emulsified JME-Diesel blend (B20). The findings suggest that the inclusion of nano Fe2O3 and SiO2 in the fuel blend can enhance engine efficiency while reducing harmful exhaust emissions.