The application of ceramic Nanofiltration (NF) membrane in brackish water treatment is increasing due to strict water quality standards. Ceramic NF is a widely used membrane process and has replaced reverse osmosis (RO) membranes in many applications due to lower energy consumption and higher flux rates. This work aims to study the separation performance of tubular ceramic TiO2 Nanofiltration membrane at low-pressure (2 bar) for single and tertiary salt mixture separation. The results showed that the rejection of ions is ordered as follows: R (Cl1-) ion size > R calcium (Ca2+) ion size > R sodium (Na1+) ion size > R magnesium (Mg2+) ion size. Moreover, the highest Cl1- rejection was about 46%, the highest Ca2+ and Mg2+ rejection was about 44%, and the highest Na1+ rejection was about 37%. The pure water flux through the investigated ceramic NF membrane for distilled water was calculated to be 5.29 x 10-7 m3 s-1 m-2 bar-1, and this flux was dropped down for the salt mixture feed to 2.56 x 10-7 m3 s-1 m-2 bar-1 due to the presence of salt particles in the feed.