This study was conducted to analysis of the Environmental Sensitivity Index (ESI) for anticipating the effect of oil spills on the environment in coastal areas. The study location is the coastal area and waters of the Karas District, Fakfak Regency, West Papua Province, Indonesia. The purpose of the study is to determine the priority of areas that are sensitive to oil spills. This method was carried out by scoring each unit of land based on vulnerability, conservation, and social values. ESI Analysis was carried out through geographic information systems and classified into 5 classes of sensitivity levels. The land use classification was carried out through satellite imagery and field surveys conducted in December 2018. The results of resource classification can be divided into 16 classes. The ESI analysis showed that most (51%) were categorized as insensitive, sensitive low 24%, very sensitive 15%, moderately sensitive 6%, and sensitive 4%. Although most are not sensitive, it should be followed by effective environmental protection to maintain sustainable development.