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SARS-CoV-2 vaccines from A to Z: A Review of the current challenges

  • Authors (legacy)
    Corresponding: Ghada Abd-Elmonsef Mahmoud
    Co-authors: Muhammad J. Albalaty, Hagar F. Forsan, Sohaila S. Awad, Nehal E. Elsadek, Gehan A. Abdel Rahman, Mona Shaban E. M. BadawyW, Eman K. M. Khalfallah, Eman Sayed El-Wakil, Lamiaa Ibrahim Ahmed, Zeinab I. Ali, Asmaa S. Nofal, Reem M. Elsapagh, Amira M. Gomaa, Fathia H.E Bougafa, Somaya Abdulbaset Mahmoud, Mariam A. Moustafa, Fatma M. Ali, Hanaa M. Barakat, Aya M. Kandeel, Aya A. El Sebaei, Ghada Abd-Elmonsef Mahmoud
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  • gnest_04651_published.pdf
  • Paper ID
    gnest_04651
  • Paper status
    Published
  • Date paper submitted
  • Date paper accepted
  • Date paper online
DOI
https://doi.org/10.30955/gnj.004651
Graphical abstract
Abstract

COVID-19 pandemic is a major worldwide health disaster firstly reported in December 2019. The Food and Drug Administration (FDA) has offered the public hope of halting it, authorizing vaccinations for emergency use with more than 85% efficacy against serious acute respiratory syndrome (SARS-CoV-2). Recent outbreaks of SARS-CoV-2 variations including spike-protein mutations, the key vaccines viral target for immune response, have prompted a thorough investigation into the vaccine's long-term effectiveness. Consequently, this review assayed the details on SARS-CoV-2 infection mechanism and how to control the infection by different types of SARS-CoV-2 vaccines, and their effectiveness against other mutant strains. Additionally, the review summarized the different complaints which have been recorded after vaccination. In conclusion, these negative effects must be constantly weighed against the predicted advantages in terms of disease prevention. Although COVID-19 vaccination is recommended for everyone aged 5 years and older, SARS-CoV-2 is high likely to continue to be a pandemic infectious as a result of the broadcasting of variants of the virus. Therefore, a booster vaccination, wearing a mask, and social distancing should be maintained.

Keywords
SARS-CoV-2 vaccines Covid-19 Neutralizing antibodies Lambada mutation Delta mutation Mutant Omicron.
Cite this article
Muhammad, J. et al. (2023) “SARS-CoV-2 vaccines from A to Z: A Review of the current challenges”, Global NEST Journal, 25(4). Available at: https://doi.org/10.30955/gnj.004651.
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  • gnest_04651_published.pdf