In this work, the effectiveness of electro-Fenton process degradation of sodium dodecylbenzene sulfonate (SDBS) anionic surfactant in acidic wastewater was investigated. Taguchi method was applied to study the effect of process parameters on oxidation of SDBS pollutant. An orthogonal array L9 experimental design that allows investigating the simultaneous variation of current density, initial acidity of wastewater, and the initial SDBS concentration was employed to evaluate the effect of these parameters as control factors. Taguchi experimental design in dynamic sense was carried out with electrolysis time chosen as signal factor. Each experiment comprises the addition of peroxide (170 mg l-1; 0.005M) as a fixed component of Fenton's reagent and NaCl (1.5 mg l-1) as supportive electrolyte. The results revealed that SDBS degradation in acidic aqueous phase, can reached high values by the electro-Fenton process. The estimation of linear model coefficients for S/N (signal to noise) ratios expression has acceptable fitness of 93.5% with the selected control and signal factors. Main effects and analysis of variance (ANOVA) indicates that the current density and the acidity have high impact on electro-Fenton degradation of SDBS process with high sum of squares and low p-values that signifies the 0.05 α-level. Moreover, Taguchi optimal analysis indicates that high S/N ratio of response can be obtained with 0.3 mA cm-2 current density,
pH=2 initial acidity of wastewater, and 10 mg l-1 initial SDBS surfactant concentration.