Non-point sources pollution from highway runoff is among the most important reasons for surface and ground waters degradation. Atmospheric deposition, exhaust emissions, pavement wear and tire wear all have been found to be crucial pollutants in highway runoff. The most critical pollutants included in the runoff of interurban roads such as total suspended solids, heavy metals, chlorides and nutrients, together with the factors affecting their concentration are been investigated. Existing legislation about drainage and highway stormwater management in United States and European Union as well as the federal agencies of the United States which have the responsibility to regulate drainage and stormwater management are also presented. Water pollution concerns in the Unites States are mainly addressed through the Federal Water Pollution Control Act of 1972, known as the Clean Water Act. Provisions within the Clean Water Act require all states to implement regulations in order to reduce the pollutant mass loading prior to discharging into water recipients. In European Union the Water Framework Directive 2000/60/EC sets common goals for the water management and created an overall water policy for management at an international level.