Genotoxic evaluation of newly synthesized organometallic compounds of tinView Crossref metadata(active tab) <div id="edit-xml" class="form-item form-type-item"> <?xml version="1.0"?> <doi_batch version="4.4.1" xmlns="http://www.crossref.org/schema/4.4.1" xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.crossref.org/schema/4.4.1 http://www.crossref.org/schemas/crossref4.4.1.xsd"><head><doi_batch_id>000696</doi_batch_id><timestamp>1714045662</timestamp><depositor><depositor_name>University of the Aegean</depositor_name><email_address>uoa@university.com</email_address></depositor><registrant>Global NEST Journal</registrant></head><body><journal><journal_metadata><full_title>Global NEST Journal</full_title><full_title>Global NEST: the international Journal</full_title><issn media_type="print">1790-7632</issn><issn media_type="electronic">2241-777X</issn></journal_metadata><journal_issue><titles><title>Issue 3</title></titles><publication_date><month>09</month><year>2024</year></publication_date><journal_volume><volume>17</volume></journal_volume><issue>3</issue></journal_issue><journal_article><titles><title>Genotoxic evaluation of newly synthesized organometallic compounds of tin</title></titles><abstract xmlns="http://www.ncbi.nlm.nih.gov/JATS1"><p><p>The genotoxic effects of organometallic tin(II) and tin(IV) complexes namely L<sub>OEt</sub>SnCl (<strong>5</strong>), L*<sub>OEt</sub>SnCl (<strong>6</strong>), L<sub>OEt</sub>SnPh<sub>3</sub> (<strong>7</strong>), L*<sub>OEt</sub>SnPh<sub>3</sub> (<strong>8</strong>), incorporating the oxygen tripodal ligands [(<em>η</em><sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Co{P(OEt)<sub>2</sub>O}<sub>3</sub>]<sup>-</sup>, {R = H, (L<sub>OEt</sub><sup>-</sup>) (<strong>3</strong>); R = Me (L*<sub>OEt</sub><sup>-</sup>) (<strong>4</strong>)} (Klaui type ligands), were investigated using the Cytokinesis Block Micronucleus assay in human lymphocytes cultures. For comparison the precursors NaL<sub>OEt</sub> (<strong>3</strong>), NaL*<sub>OEt</sub> (<strong>4</strong>), SnCl<sub>2</sub>•2H<sub>2</sub>O (<strong>1</strong>) and Ph<sub>3</sub>SnCl (<strong>2</strong>), were also studied.</p> <p>Statistically significant differences in comparison with the control in the micronuclei frequencies were seen at the concentrations: 75 μM for complex (<strong>5</strong>), 50 μM for complex (<strong>6</strong>), 20, 50, 75 μM for complex (<strong>8</strong>). No statistically significant differences were observed between controls and all the rest tested concentrations for all chemicals examined.</p> <div> <p>The cytotoxic effect was evaluated by the Cytokinesis Block Proliferation Index. Regarding this index, the precursor (<strong>1</strong>) is not cytotoxic at all tested concentrations. Complexes (<strong>3</strong>), (<strong>4</strong>) and (<strong>5</strong>) induced cytotoxicity at the concentrations of 20, 50 and 75 μM, while complexes (<strong>6</strong>) and (<strong>8</strong>) were cytotoxic at all tested concentrations. Complex (<strong>7</strong>) was cytotoxic at 5, 10 and 20 μM but extremely toxic at 50 and 75 μM. Finally complex (<strong>2</strong>) was extremely toxic at all tested concentrations except at 1 μM. </p> </div> <p> </p> </p></abstract><publication_date><month>08</month><day>26</day><year>2015</year></publication_date><pages><first_page>574</first_page><last_page>582</last_page></pages><publisher_item><identifier id_type="pii">gnest_01622</identifier></publisher_item><doi_data><doi>10.30955/gnj.001622</doi><timestamp>1714045662</timestamp><resource>https://journal.gnest.org/publication/gnest_01622</resource></doi_data></journal_article></journal></body></doi_batch> </div>
