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New disinfection by-product issues: emerging DBPs and alternative routes of exposureView Crossref metadata(active tab) <div id="edit-xml" class="form-item form-type-item"> <?xml version="1.0"?> <doi_batch version="4.4.1" xmlns="http://www.crossref.org/schema/4.4.1" xmlns:jats="http://www.ncbi.nlm.nih.gov/JATS1" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.crossref.org/schema/4.4.1 http://www.crossref.org/schemas/crossref4.4.1.xsd"><head><doi_batch_id>000696</doi_batch_id><timestamp>1714061126</timestamp><depositor><depositor_name>University of the Aegean</depositor_name><email_address>uoa@university.com</email_address></depositor><registrant>Global NEST Journal</registrant></head><body><journal><journal_metadata><full_title>Global NEST Journal</full_title><full_title>Global NEST: the international Journal</full_title><issn media_type="print">1790-7632</issn><issn media_type="electronic">2241-777X</issn></journal_metadata><journal_issue><titles><title>Issue 1</title></titles><publication_date><month>03</month><year>2024</year></publication_date><journal_volume><volume>7</volume></journal_volume><issue>1</issue></journal_issue><journal_article><titles><title>New disinfection by-product issues: emerging DBPs and alternative routes of exposure</title></titles><abstract xmlns="http://www.ncbi.nlm.nih.gov/JATS1"><p>This paper discusses current issues with drinking water disinfection by-products (DBPs), which include emerging (unregulated) DBPs that can be formed at greater levels with alternative disinfectants (as compared to chlorine) and routes of human exposure (which include inhalation and dermal exposure studies, in addition to ingestion). Health effects driving DBP research include the recently observed reproductive/developmental effects (including spontaneous abortion) observed in epidemiologic studies, as well as the discrepancy between the types of cancer observed in animal studies for regulated DBPs (mostly liver cancer) and the types of cancer observed in human epidemiologic studies (mostly bladder cancer). Emerging DBPs discussed in this paper include iodo-acids, bromonitromethanes, iodo-trihalomethanes (THMs), brominated forms of MX, bromoamides, a bromopyrrole, and nitrosodimethylamine (NDMA) and other nitrosamines. Recent toxicity studies have revealed that several of these DBPs are more genotoxic (in isolated cells) than many of the DBPs currently regulated, and new occurrence data have revealed that many of these DBPs can, in some cases, be present at levels comparable to regulated DBPs. Of the alternative disinfectants, chloramination appears to increase the formation of iodo-acids, iodo-THMs, and NDMA and other nitrosamines, relative to chlorine. Preozonation appears to increase the formation of halonitromethanes.</p></abstract><publication_date><month>04</month><day>29</day><year>2013</year></publication_date><pages><first_page>43</first_page><last_page>60</last_page></pages><publisher_item><identifier id_type="pii">320</identifier></publisher_item><doi_data><doi>10.30955/gnj.000320</doi><timestamp>1714061126</timestamp><resource>https://journal.gnest.org/publication/320</resource></doi_data></journal_article></journal></body></doi_batch> </div>
